Sean Davidson
Research Technician
B.Eng. McGill
University (1997), M.A.Sc. University of Toronto (1999)
Treatment Planning for Minimally Invasive Therapies
The focus of my work has been the development of a software platform for the
treatment planning of minimally invasive energy-based therapies. The platform
can currently be used to develop treatment plans for:
Currently, work is being done to validate the treatment planning simulations.
The laser thermal therapy simulations are being validated against experiments
in tissue-equivalent phantom materials and ex-vivo bovine liver. Some of the
steps required to validate these simulations are:
Publications
U. Lindner, N. Lawrentschuk, R.A. Weersink, O. Raz, E. Hlasny, M.S. Sussman,
S.R.H. Davidson, M.R. Gertner, J. Trachtenberg, Construction
and Evaluation of an Anatomically Correct Multi-Image Modality Compatible
Phantom for Prostate Cancer Focal Ablation, Journal of Urology, 184(1):
352-357, 2010.
U. Lindner, N. Lawrentschuk, R.A. Weersink, S.R.H. Davidson, O. Raz, E. Hlasny, D.L. Langer, M.R. Gertner, T van der Kwast, M.A. Haider, J. Trachtenberg, Focal Laser Ablation for Prostate Cancer Followed by Radical Prostatectomy: Validation of Focal Therapy and Imaging Accuracy, Journal of Urology 183(4): Supplement e183-e183, 2010
O. Raz, M.A. Haider, S.R.H. Davidson, U. Lindner, E. Hlasny, R.A. Weersink, M.R. Gertner, W. Kucharcyzk, S.A. McCluskey, J. Trachtenberg, Real-Time Magnetic Resonance Imaging-Guided Focal Laser Therapy in Patients with Low-Risk Prostate Cancer, European Urology 58(1): 173-177, 2010.
U. Lindner, R.A. Weersink, M.A. Haider, M.R. Gertner, S.R.H. Davidson, M. Atri, B.C. Wilson, A. Fenster, J. Trachtenberg, Image Guided Photothermal Focal Therapy for Localized Prostate Cancer: Phase I Trial, Journal of Urology 182(4): 1371-1377, 2009.
S.R.H. Davidson, R.A. Weersink, M.A. Haider, M.R. Gertner, A. Bogaards, D. Giewercer, A. Scherz, M.D. Sherar, M. Elhilali, J.L. Chin, J. Trachtenberg, B.C. Wilson, Treatment Planning and Dose Analysis for Interstitial Photodynamic Therapy of Prostate Cancer, Physics in Medicine and Biology, 54(8): 2293-2313, 2009.
J. Trachtenberg, R.A. Weersink, S.R.H. Davidson, M.A. Haider, A.Bogaards, M.R. Gertner, A. Evans, A. Scherz, J. Savard, J.L. Chin, B.C. Wilson, M. Elhilali, Vascular-Targeted Photodynamic Therapy (Padoporfin, WST09) for Recurrent Prostate Cancer after Failure of External Beam Radiotherapy: A Study of Escalating Light Doses, BJU International, 102(5): 556-562, 2008.
M.A. Haider, S.R.H. Davidson, A.V. Kale, R.A. Weersink, A.J. Evans, A. Toi, M.R. Gertner, A. Bogaards, B.C. Wilson, J.L. Chin, M. Elhilali, J. Trachtenberg, Prostate Gland: MR Imagaing Appearance after Vascular Targeted Photodynamic Therapy with Palladium-Bacteriopheophorbide, Radiology, 244(1): 196-204, 2007.
R.A. Weersink, A. Bogaards, M. Gertner, S.R.H. Davidson, K. Zhang, G. Netchev, J. Trachtenberg, B.C. Wilson, Techniques for Delivery and Monitoring of TOOKAD (WST09)-Mediated Photodynamic Therapy of the Prostate: Clinical Experience and Practicalities, Journal of Photochemistry and Photobiology B: Biology, 79 (3): 211-222, 2005.
S.R.H. Davidson, I.A. Vitkin, M.D. Sherar, W.M. Whelan, Characterization of Measurement Artefacts in Fluoroptic Temperature Sensors: Implications for Laser Thermal Therapy at 810 nm, Lasers in Surgery and Medicine, 36 (4): 289-296, 2005.
W.M. Whelan, S.R.H. Davidson, L.C.L. Chin, I.A. Vitkin, A Novel Strategy for Monitoring Laser Thermal Therapy Based on Changes in Optothermal Properties of Heated Tissues, International Journal of Thermophysics, 26 (1): 233-241, 2005.
M.D. Sherar, J. Trachtenberg, S.R.H. Davidson, M.R. Gertner, Interstitial Microwave Thermal Therapy and Its Application to the Treatment of Recurrent Prostate Cancer, International Journal of Hyperthermia, 20 (7): 757-768, 2004.
A.S. Gladman, S.R.H. Davidson, A.C. Easty, M.L. Joy, M.D. Sherar, Infrared thermographic SAR measurements of interstitial hyperthermia applicators: Errors due to thermal conduction and convection. International Journal of Hyperthermia 20 (5): 539-555, 2004.
M.D. Sherar, J. Trachtenberg, S.R.H. Davidson, C. McCann, C.K.K. Yue, M.R. Gertner, Interstitial Microwave Thermal Therapy for Prostate Cancer, Journal of Endourology 17 (8): 617-625, 2003.
C. McCann, J.K. Kumaradas, M.R.Gertner, S.R.H. Davidson, A.M. Dolan, M.D. Sherar, Feasibility of Salvage Interstitial Microwave Thermal Therapy for Prostate Carcinoma Following Failed Brachytherapy: Studies in a Tissue Equivalent Phantom, Physics in Medicine and Biology 48 (8): 1041-1052, 2003.
S.R.H. Davidson, M.D. Sherar,
Theoretical
Modelling, Experimental Studies and Clinical Simulations of Urethral Cooling
Catheters for use during Prostate Thermal Therapy, Physics in Medicine
and Biology 48 (6): 729-744, 2003.
S.R.H. Davidson, M.D. Sherar, Measurement
of the Thermal Conductivity of Polyacrylamide Tissue-Equivalent Material, International Journal of Hyperthermia, 19 (5): 551-562,
2003.
M.D. Sherar, A.S. Gladman, S.R.H. Davidson, J. Trachtenberg,
M.R.Gertner,
Helical Antenna Arrays for Interstitial Microwave Thermal Therapy for
Prostate Cancer: Tissue Phantom Testing and Simulations for Treatment,
Physics in Medicine and Biology 46 (7): 1905-1918, 2001.
Conference Papers
R.A. Weersink, A. Bogaards, M. Gertner, S. Davidson, K. Zhang,
G. Netchev, D.J. Giewercer, J. Trachtenberg, B.C. Wilson, Optical
Delivery and Monitoring of Photodynamic Therapy of Prostate Cancer,
Photonics North 2004: Photonic Applications in Astronomy, Biomedicine, Imaging,
Materials Processing, and Education, Ottawa, Canada, Proceedings of SPIE 5578:
117-127, 2004.
M.A. Haider, B. Wilson, S. Davidson, R. Weersink, M. Gertner, J. Trachtenberg, Dynamic Contrast-Enhanced MRI as a Predictor of Residual Tumor after Photodynamic Therapy with TOOKAD (WST09) for Locally Recurrent Prostate Carcinoma after Radiation Therapy, ISMRM 14th Scientific Meeting and Exhibition, Seattle, May 6-12, 2006.
610 University Avenue
Toronto, Ontario
CANADA M5G 2M9
Fax: (416) 946-2086
e-mail: davidson@uhnres.utoronto.ca